Information about The chemiosmotic theory of Peter Mitchell proposes a mechanism for the tight coupling of electron transport via the respiratory chain to the process of oxidative phosphorylation.Which of the following options is predicted by the theory?a)A proton gradient across the inner mitochondrial membrane generated by electron transport drives ATP synthesisb)The electrochemical potential difference across the inner mitochondrial membrane caused by electron transport is positive on the matrix side.c)Protons are pumped across the inner mitochondrial membrane as electrons pass down the respiratory chain.d)An increase in the permeability of the inner mitochondrial membrane to protons uncouples the processes of electron transport and oxidative phosphorylation.Correct answer is option 'A,C,D'. The Question and answers have been prepared Can you explain this answer? for IIT JAM 2023 is part of IIT JAM preparation. The chemiosmotic theory of Peter Mitchell proposes a mechanism for the tight coupling of electron transport via the respiratory chain to the process of oxidative phosphorylation.Which of the following options is predicted by the theory?a)A proton gradient across the inner mitochondrial membrane generated by electron transport drives ATP synthesisb)The electrochemical potential difference across the inner mitochondrial membrane caused by electron transport is positive on the matrix side.c)Protons are pumped across the inner mitochondrial membrane as electrons pass down the respiratory chain.d)An increase in the permeability of the inner mitochondrial membrane to protons uncouples the processes of electron transport and oxidative phosphorylation.Correct answer is option 'A,C,D'. ![]() In summary, the chemiosmotic theory of Peter Mitchell predicts that a proton gradient across the inner mitochondrial membrane drives ATP synthesis, protons are pumped across the inner mitochondrial membrane as electrons pass down the respiratory chain, and an increase in the permeability of the inner mitochondrial membrane to protons uncouples the processes of electron transport and oxidative phosphorylation. This means that if the inner mitochondrial membrane becomes more permeable to protons, the proton gradient that drives ATP synthesis will dissipate, and the coupling between electron transport and ATP synthesis will be lost. ![]() The energy released during electron transport is utilized to pump protons from the matrix side to the intermembrane space, thus establishing a proton gradient across the inner mitochondrial membrane.ĭ) Increase in Permeability of Inner Mitochondrial Membrane Uncouples Processesįinally, the chemiosmotic theory predicts that an increase in the permeability of the inner mitochondrial membrane to protons uncouples the processes of electron transport and oxidative phosphorylation. The theory also predicts that protons are pumped across the inner mitochondrial membrane as electrons pass down the respiratory chain. Thus, the theory predicts that a proton gradient across the inner mitochondrial membrane drives ATP synthesis.Ĭ) Protons are Pumped Across the Inner Mitochondrial Membrane ![]() This proton gradient is then utilized by ATP synthase to drive the synthesis of ATP from ADP and inorganic phosphate. ![]() The theory predicts the following:Īccording to the chemiosmotic theory, a proton gradient is generated across the inner mitochondrial membrane by electron transport. The chemiosmotic theory proposed by Peter Mitchell explains the mechanism of the tight coupling of electron transport via the respiratory chain to the process of oxidative phosphorylation.
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